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Molecular basis of substrate selection by the N-end rule adaptor protein ClpS

The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with peptides containing N-terminal phenylalanine, leucine, and tryptophan. These s...

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Détails bibliographiques
Auteurs principaux: Román-Hernández, Giselle, Grant, Robert A., Sauer, Robert T., Baker, Tania A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690016/
https://ncbi.nlm.nih.gov/pubmed/19451643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903614106
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