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Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates
The ClpS adaptor collaborates with the AAA+ ClpAP protease to recognize and degrade N-degron substrates. ClpS binds the substrate N-degron and assembles into a high-affinity ClpS-substrate-ClpA complex, but how the N-degron is transferred from ClpS to the axial pore of the AAA+ ClpA unfoldase to ini...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169940/ https://ncbi.nlm.nih.gov/pubmed/25187555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414933111 |
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