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Engineering Synthetic Adaptors and Substrates for Controlled ClpXP Degradation
Facile control of targeted intracellular protein degradation has many potential uses in basic science and biotechnology. One promising approach to this goal is to redesign adaptor proteins, which can regulate proteolytic specificity by tethering substrates to energy-dependent AAA+ proteases. Using t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2755909/ https://ncbi.nlm.nih.gov/pubmed/19549779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017624 |
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