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SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags

The ssrA-degradation tag sequence contains contiguous binding sites for the SspB adaptor and the ClpX component of the ClpXP protease. Although SspB normally enhances ClpXP degradation of ssrA-tagged substrates, it inhibits proteolysis under conditions that prevent tethering to ClpX. By increasing t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hersch, Greg L., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514447/
https://ncbi.nlm.nih.gov/pubmed/15297609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404733101
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