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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Fei, Xue, Bell, Tristan A, Barkow, Sarah R, Baker, Tania A, Sauer, Robert T
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652416/
https://ncbi.nlm.nih.gov/pubmed/33089779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61496
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