Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and translocates specific protein substrates into the degradation chamber of ClpP. We present cryo-EM studies of the E. coli enzyme that show how asymmetric hexameric rings of ClpX bind symmetric heptameric rings of ClpP...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Fei, Xue, Bell, Tristan A, Jenni, Simon, Stinson, Benjamin M, Baker, Tania A, Harrison, Stephen C, Sauer, Robert T
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112951/
https://ncbi.nlm.nih.gov/pubmed/32108573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52774
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