Multistep substrate binding and engagement by the AAA+ ClpXP protease

Escherichia coli ClpXP is one of the most thoroughly studied AAA+ proteases, but relatively little is known about the reactions that allow it to bind and then engage specific protein substrates before the adenosine triphosphate (ATP)-fueled mechanical unfolding and translocation steps that lead to p...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Saunders, Reuben A., Stinson, Benjamin M., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668067/
https://ncbi.nlm.nih.gov/pubmed/33106413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010804117
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