Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease

ClpXP is an ATP-fueled molecular machine that unfolds and degrades target proteins. ClpX, an AAA+ enzyme, recognizes specific proteins, and then uses cycles of ATP hydrolysis to denature any native structure and to translocate the unfolded polypeptide into ClpP for degradation. Here, we develop and...

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Detalhes bibliográficos
Main Authors: Shin, Yongdae, Davis, Joseph H., Brau, Ricardo R., Martin, Andreas, Kenniston, Jon A., Baker, Tania A., Sauer, Robert T., Lang, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773733/
https://ncbi.nlm.nih.gov/pubmed/19892734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910484106
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