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Stepwise unfolding of a β-barrel protein by the AAA+ ClpXP protease

In the AAA+ ClpXP protease, ClpX uses the energy of ATP binding and hydrolysis to unfold proteins before translocating them into ClpP for degradation. For proteins with C-terminal ssrA tags, ClpXP pulls on the tag to initiate unfolding and subsequent degradation. Here, we demonstrate that an initial...

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Bibliografski detalji
Glavni autori: Nager, Andrew R., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184388/
https://ncbi.nlm.nih.gov/pubmed/21821046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.041
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