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Stepwise unfolding of a β-barrel protein by the AAA+ ClpXP protease
In the AAA+ ClpXP protease, ClpX uses the energy of ATP binding and hydrolysis to unfold proteins before translocating them into ClpP for degradation. For proteins with C-terminal ssrA tags, ClpXP pulls on the tag to initiate unfolding and subsequent degradation. Here, we demonstrate that an initial...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184388/ https://ncbi.nlm.nih.gov/pubmed/21821046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.07.041 |
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