Polypeptide translocation by the AAA+ ClpXP protease machine

In the AAA+ ClpXP protease, ClpX uses repeated cycles of ATP hydrolysis to pull native proteins apart and to translocate the denatured polypeptide into ClpP for degradation. Here, we probe polypeptide features important for translocation. ClpXP degrades diverse synthetic peptide substrates despite m...

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Bibliografiske detaljer
Main Authors: Barkow, Sarah R., Levchenko, Igor, Baker, Tania A., Sauer, Robert T.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718738/
https://ncbi.nlm.nih.gov/pubmed/19549599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.05.007
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