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Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease
ClpXP is an ATP-fueled molecular machine that unfolds and degrades target proteins. ClpX, an AAA+ enzyme, recognizes specific proteins, and then uses cycles of ATP hydrolysis to denature any native structure and to translocate the unfolded polypeptide into ClpP for degradation. Here, we develop and...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773733/ https://ncbi.nlm.nih.gov/pubmed/19892734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910484106 |
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