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Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease

ClpA is a hexameric double-ring AAA+ unfoldase/translocase that functions with the ClpP peptidase to degrade proteins that are damaged or unneeded. How the 12 ATPase active sites of ClpA, 6 in the D1 ring and 6 in the D2 ring, work together to fuel ATP-dependent degradation is not understood. We use...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Zuromski, Kristin L., Sauer, Robert T., Baker, Tania A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568338/
https://ncbi.nlm.nih.gov/pubmed/33020301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014407117
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