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Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP

ClpA, a bacterial member of the Clp/Hsp100 chaperone family, is an ATP-dependent molecular chaperone and the regulatory component of the ATP-dependent ClpAP protease. To study the mechanism of binding and unfolding of proteins by ClpA and translocation to ClpP, we used as a model substrate a fusion...

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Detalhes bibliográficos
Main Authors: Hoskins, Joel R., Singh, Satyendra K., Maurizi, Michael R., Wickner, Sue
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16792/
https://ncbi.nlm.nih.gov/pubmed/10922051
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