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ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase. Based on asymmetric features of cryo-EM structures and a sequential hand-over-hand model of substrate translocation,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kim, Sora, Zuromski, Kristin L, Bell, Tristan A, Sauer, Robert T, Baker, Tania A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707817/
https://ncbi.nlm.nih.gov/pubmed/33258771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61451
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