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The non-dominant AAA+ ring in the ClpAP protease functions as an anti-stalling motor to accelerate protein unfolding and translocation
ATP-powered unfoldases containing D1 and D2 AAA+ rings play important roles in protein homeostasis, but uncertainty about the function of each ring remains. Here we use single-molecule optical-tweezers to assay mechanical unfolding and translocation by a variant of the ClpAP protease containing an A...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7888974/ https://ncbi.nlm.nih.gov/pubmed/32101742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.110 |
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