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Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis
The ClpAP complex is a conserved bacterial protease that unfolds and degrades proteins targeted for destruction. Two ClpA AAA+ hexamer rings power substrate unfolding and translocation into the ClpP proteolytic chamber. Here, we determined high-resolution structures of wild-type Escherichia coli Clp...
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| 出版年: | Nat Struct Mol Biol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529148/ https://ncbi.nlm.nih.gov/pubmed/32313240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0409-5 |
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