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Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis
The ClpAP complex is a conserved bacterial protease that unfolds and degrades proteins targeted for destruction. Two ClpA AAA+ hexamer rings power substrate unfolding and translocation into the ClpP proteolytic chamber. Here, we determined high-resolution structures of wild-type Escherichia coli Clp...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529148/ https://ncbi.nlm.nih.gov/pubmed/32313240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0409-5 |
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