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The AAA+ ClpX machine unfolds a keystone subunit to remodel the Mu transpososome

A hyperstable complex of the tetrameric MuA transposase with recombined DNA must be remodeled to allow subsequent DNA replication. ClpX, a AAA+ enzyme, fulfills this function by unfolding one transpososome subunit. Which MuA subunit is extracted, and how complex destabilization relates to establishm...

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Detalhes bibliográficos
Main Authors: Abdelhakim, Aliaa H., Sauer, Robert T., Baker, Tania A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823858/
https://ncbi.nlm.nih.gov/pubmed/20133746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910905106
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