Ureadepsipeptides as ClpP Activators

Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill non-growing bacteria represents a new opportunity to combat deep-seated biofilm infections. However, the acyl...

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Foilsithe in:ACS Infect Dis
Main Authors: Griffith, Elizabeth C., Zhao, Ying, Singh, Aman P., Conlon, Brian P., Tangallapally, Rajendra, Shadrick, William R., Liu, Jiuyu, Wallace, Miranda J., Yang, Lei, Elmore, John M., Li, Yong, Zheng, Zhong, Miller, Darcie J., Cheramie, Martin N., Lee, Robin B., LaFleur, Michael D., Lewis, Kim, Lee, Richard E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916429/
https://ncbi.nlm.nih.gov/pubmed/31588734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00245
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