Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth

Continuous exposure of a pancreatic cancer cell line MIA PaCa-2 (Mia(S)) to gemcitabine resulted in the formation of a gemcitabine-resistant subline (Mia(R)). In an effort to discover kinase inhibitors that inhibited Mia(R) growth, Mia(R) cells were exposed to kinase inhibitors (PKIS-1 library) in a...

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Bibliografiska uppgifter
I publikationen:SLAS Discov
Huvudupphovsmän: Krulikas, Linas J., McDonald, Ian M., Lee, Benjamin, Okumu, Denis O., East, Michael P., Gilbert, Thomas S. K., Herring, Laura E., Golitz, Brian T., Wells, Carrow I., Axtman, Allison D., Zuercher, William J., Willson, Timothy M., Kireev, Dmitri, Yeh, Jen Jen, Johnson, Gary L., Baines, Antonio T., Graves, Lee M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102050/
https://ncbi.nlm.nih.gov/pubmed/29742358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218773045
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