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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

SGC-GAK-1 (<b>1</b>) is a potent, selective, cell-active chemical probe for cyclin G-associated kinase (GAK). However, <b>1</b> was rapidly metabolized in mouse liver microsomes by cytochrome P450-mediated oxidation, displaying rapid clearance in liver microsomes and in mice,...

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Autors principals: Christopher R. M. Asquith, James M. Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M. Elkins, Julie E. Pickett, Carrow I. Wells, Zengbiao Li, Timothy M. Willson, William J. Zuercher
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2019-11-01
Col·lecció:Molecules
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Accés en línia:https://www.mdpi.com/1420-3049/24/22/4016
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