Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes

Small heterodimer partner (SHP) plays important roles in diverse biological processes by directly interacting with transcription factors and inhibiting their activities. SHP has been designated an orphan nuclear receptor, but whether its activity can be modulated by ligands has been a long-standing...

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Detalhes bibliográficos
Main Authors: Miao, Ji, Choi, Sung-E, Seok, Sun Mi, Yang, Linda, Zuercher, William J., Xu, Yong, Willson, Timothy M., Xu, H. Eric, Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125094/
https://ncbi.nlm.nih.gov/pubmed/21566081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0033
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