Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner

The functional interaction between the orphan nuclear receptors small heterodimer partner (SHP) and liver receptor homolog 1 (LRH-1), where SHP binds to LRH-1 and represses its constitutive transcriptional activity, is crucial for regulating genes involved in cholesterol homeostasis. Here, we report...

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Detalhes bibliográficos
Main Authors: Li, Yong, Choi, Mihwa, Suino, Kelly, Kovach, Amanda, Daugherty, Jennifer, Kliewer, Steven A., Xu, H. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157103/
https://ncbi.nlm.nih.gov/pubmed/15976031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501204102
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