AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional repression of gluconeogenic enzyme gene expression. Here, we show that SHP inhibited protein kinase A-mediated transcriptional activity of cAMP-response element-binding protein (CREB), a major regulator of gl...

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Hauptverfasser: Lee, Ji-Min, Seo, Woo-Young, Song, Kwang-Hoon, Chanda, Dipanjan, Kim, Yong Deuk, Kim, Don-Kyu, Lee, Min-Woo, Ryu, Dongryeol, Kim, Yong-Hoon, Noh, Jung-Ran, Lee, Chul-Ho, Chiang, John Y. L., Koo, Seung-Hoi, Choi, Hueng-Sik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952219/
https://ncbi.nlm.nih.gov/pubmed/20688914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134890
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