Structural insights into gene repression by the orphan nuclear receptor SHP

Small heterodimer partner (SHP) is an orphan nuclear receptor that functions as a transcriptional repressor to regulate bile acid and cholesterol homeostasis. Although the precise mechanism whereby SHP represses transcription is not known, E1A-like inhibitor of differentiation (EID1) was isolated as...

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Detalhes bibliográficos
Main Authors: Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Zechner, Christoph, Suino-Powell, Kelly M., Kliewer, Steven A., Melcher, Karsten, Mangelsdorf, David J., Xu, H. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896210/
https://ncbi.nlm.nih.gov/pubmed/24379397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322827111
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