Mutational Hypersensitivity of a Gene Regulatory Protein: Saccharomyces cerevisiae Gal80p

Por Melcher, Karsten
Publicado em 2005

Gal80–Gal80 interaction on adjacent Gal4p binding sites is required for complete GAL gene repression

Por Melcher, Karsten, Xu, H.Eric
Publicado em 2001

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

Por Pal, Kuntal, Melcher, Karsten, Xu, H Eric
Publicado em 2012

The cryo-electron microscopy structure of γ-Secretase: towards complex assembly, substrate recognition and a catalytic mechanism

Por Kang, Yanyong, Melcher, Karsten, Xu, H. Eric
Publicado no Natl Sci Rev (2015)

Thirsty plants and beyond: Structural mechanisms of abscisic acid perception and signaling

Por Melcher, Karsten, Zhou, X. Edward, Xu, H. Eric
Publicado em 2010

Structure and activation of rhodopsin

Por Zhou, X Edward, Melcher, Karsten, Xu, H Eric
Publicado em 2012

Abscisic acid perception and signaling: structural mechanisms and applications

Por Ng, Ley Moy, Melcher, Karsten, Teh, Bin Tean, Xu, H Eric
Publicado no Acta Pharmacol Sin (2014)

Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

Por Wu, Zhong-shan, Cheng, Hao, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado no Acta Pharmacol Sin (2015)

Androgen receptor: structure, role in prostate cancer and drug discovery

Por Tan, MH Eileen, Li, Jun, Xu, H Eric, Melcher, Karsten, Yong, Eu-leong
Publicado no Acta Pharmacol Sin (2015)

A structural snapshot of the rhodopsin–arrestin complex

Por Kang, Yanyong, Gao, Xiang, Zhou, X. Edward, He, Yuanzheng, Melcher, Karsten, Xu, H. Eric
Publicado no FEBS J (2015)

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

Por Xu, Ting-Hai, Yan, Yan, Kang, Yanyong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado no Cell Discov (2016)

H(2)O(2) Inhibits ABA-Signaling Protein Phosphatase HAB1

Por Sridharamurthy, Madhuri, Kovach, Amanda, Zhao, Yang, Zhu, Jian-Kang, Xu, H. Eric, Swaminathan, Kunchithapadam, Melcher, Karsten
Publicado no PLoS One (2014)

Abscisic Acid Signaling: Thermal Stability Shift Assays as Tool to Analyze Hormone Perception and Signal Transduction

Por Soon, Fen-Fen, Suino-Powell, Kelly M., Li, Jun, Yong, Eu-Leong, Xu, H. Eric, Melcher, Karsten
Publicado em 2012

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Por Ke, Jiyuan, Ma, Honglei, Gu, Xin, Thelen, Adam, Brunzelle, Joseph S., Li, Jiayang, Xu, H. Eric, Melcher, Karsten
Publicado no Sci Adv (2015)

Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro

Por Yi, Wei, Shi, Jingjing, Zhao, Guanguan, Zhou, X. Edward, Suino-Powell, Kelly, Melcher, Karsten, Xu, H. Eric
Publicado no Sci Rep (2017)

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

Por Sasi, Nanda Kumar, Tiwari, Kanchan, Soon, Fen-Fen, Bonte, Dorine, Wang, Tong, Melcher, Karsten, Xu, H. Eric, Weinreich, Michael
Publicado no PLoS One (2014)

Structural basis of the Norrin-Frizzled 4 interaction

Por Shen, Guobo, Ke, Jiyuan, Wang, Zhizhi, Cheng, Zhihong, Gu, Xin, Wei, Yuquan, Melcher, Karsten, Xu, H Eric, Xu, Wenqing
Publicado no Cell Res (2015)

Structural basis for corepressor assembly by the orphan nuclear receptor TLX

Por Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Searose-Xu, Kelvin, Zhang, Chun-Li, Tsai, Chih-Cheng, Melcher, Karsten, Xu, H. Eric
Publicado no Genes Dev (2015)

Generation and characterization of a human nanobody against VEGFR-2

Por Ma, Lin, Gu, Kai, Zhang, Cheng-hai, Chen, Xue-tao, Jiang, Yi, Melcher, Karsten, Zhang, Juan, Wang, Min, Xu, H Eric
Publicado no Acta Pharmacol Sin (2016)

An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain

Por Yin, Yanting, Zhou, X Edward, Hou, Li, Zhao, Li-Hua, Liu, Bo, Wang, Gaihong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado no Cell Discov (2016)