Structural basis for corepressor assembly by the orphan nuclear receptor TLX

The orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions primarily as a transcription repressor through recruitment of Atrophin corepressors, which bind to TLX via a conserved peptide motif termed the Atro box. Here we report crystal structures of the...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Searose-Xu, Kelvin, Zhang, Chun-Li, Tsai, Chih-Cheng, Melcher, Karsten, Xu, H. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335298/
https://ncbi.nlm.nih.gov/pubmed/25691470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254904.114
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