Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

Mutations in the amyloid precursor protein (APP) gene and the aberrant cleavage of APP by γ-secretase are associated with Alzheimer’s disease (AD). Here we have developed a simple and sensitive cell-based assay to detect APP cleavage by γ-secretase. Unexpectedly, most familial AD (FAD)-linked APP mu...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Xu, Ting-Hai, Yan, Yan, Kang, Yanyong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994064/
https://ncbi.nlm.nih.gov/pubmed/27625790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.26
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