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Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
One of the hallmarks of Alzheimer's disease is the formation of extracellular amyloid plaques that consist mainly of abnormally aggregated forms of amyloid β (Aβ) peptides. These peptides are generated by γ-secretase–catalyzed cleavage of a dimeric membrane-bound C-terminal fragment (C99) of th...
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| 發表在: | J Biol Chem |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612113/ https://ncbi.nlm.nih.gov/pubmed/28790170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789669 |
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