The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

The etiology of Alzheimer’s disease depends on the relative abundance of different amyloid-β (Aβ) peptide species. These peptides are produced by sequential proteolytic cleavage within the transmembrane helix of the 99 residue C-terminal fragment of the amyloid precursor protein (C99) by the intrame...

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Main Authors: Pester, Oxana, Barrett, Paul J., Hornburg, Daniel, Hornburg, Philipp, Pröbstle, Rasmus, Widmaier, Simon, Kutzner, Christoph, Dürrbaum, Milena, Kapurniotu, Aphrodite, Sanders, Charles R., Scharnagl, Christina, Langosch, Dieter
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560327/
https://ncbi.nlm.nih.gov/pubmed/23265086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3112093
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