TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage

TMP21 has been shown to be associated with the γ-secretase complex and can specifically regulate γ-cleavage without affecting ϵ-mediated proteolysis. To explore the basis of this activity, TMP21 modulation of γ-secretase activity was investigated independent of ϵ-cleavage using an amyloid-β precurso...

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Bibliografske podrobnosti
Main Authors: Pardossi-Piquard, Raphaëlle, Böhm, Christopher, Chen, Fusheng, Kanemoto, Soshi, Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781407/
https://ncbi.nlm.nih.gov/pubmed/19710022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059345
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