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Presenilin-Dependent γ-Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
Presenilins (PSs) are part of the γ-secretase complex that produces the amyloid β-peptide (Aβ) from its precursor [β-amyloid precursor protein (βAPP)]. Mutations in PS that cause familial Alzheimer's disease (FAD) increase Aβ production and trigger p53-dependent cell death. We demonstrate that...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Neurosci |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Society for Neuroscience
2006
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675197/ https://ncbi.nlm.nih.gov/pubmed/16763046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0651-06.2006 |
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