Presenilin-Dependent γ-Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease

Presenilins (PSs) are part of the γ-secretase complex that produces the amyloid β-peptide (Aβ) from its precursor [β-amyloid precursor protein (βAPP)]. Mutations in PS that cause familial Alzheimer's disease (FAD) increase Aβ production and trigger p53-dependent cell death. We demonstrate that...

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Pubblicato in:J Neurosci
Autori principali: Alves da Costa, Cristine, Sunyach, Claire, Pardossi-Piquard, Raphaelle, Sévalle, Jean, Vincent, Bruno, Boyer, Nicole, Kawarai, Toshitaka, Girardot, Nadège, St. George-Hyslop, Peter, Checler, Frédéric
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675197/
https://ncbi.nlm.nih.gov/pubmed/16763046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0651-06.2006
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