Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

Samankaltaisia teoksia

• The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
  Tekijä: Lauritzen, Inger, et al.
  Julkaistu: (2013)
• The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models
  Tekijä: Bécot, Anaïs, et al.
  Julkaistu: (2020)
• Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models
  Tekijä: Lauritzen, Inger, et al.
  Julkaistu: (2019)
• Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
  Tekijä: Lauritzen, Inger, et al.
  Julkaistu: (2016)
• The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus
  Tekijä: Lauritzen, Inger, et al.
  Julkaistu: (2012)