Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

Endosomal-autophagic-lysosomal (EAL) dysfunction is an early and prominent neuropathological feature of Alzheimers’s disease, yet the exact molecular mechanisms contributing to this pathology remain undefined. By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrat...

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Detalles Bibliográficos
Publicado en:Acta Neuropathol
Main Authors: Lauritzen, Inger, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Pagnotta, Sophie, Biferi, Maria-Grazia, Barkats, Martine, Lacor, Pascale, Klein, William, Bauer, Charlotte, Checler, Frederic
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2016
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947121/
https://ncbi.nlm.nih.gov/pubmed/27138984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1577-6
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