p53-dependent control of transactivation of the Pen2 promoter by presenilins

The senile plaques found in the brains of patients with Alzheimer's disease are mainly due to the accumulation of amyloid β-peptides (Aβ) that are liberated by γ-secretase, a high molecular weight complex including presenilins, PEN-2, APH-1 and nicastrin. The depletion of each of these proteins...

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Dettagli Bibliografici
Autori principali: Dunys, Julie, Sevalle, Jean, Giaime, Emilie, Pardossi-Piquard, Raphaëlle, Vitek, Michael P., Renbaum, Paul, Levy-Lahad, Ephrat, Zhang, Yun-wu, Xu, Huaxi, Checler, Frédéric, da Costa, Cristine Alves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188804/
https://ncbi.nlm.nih.gov/pubmed/19889971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.051169
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