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p53-dependent control of transactivation of the Pen2 promoter by presenilins
The senile plaques found in the brains of patients with Alzheimer's disease are mainly due to the accumulation of amyloid β-peptides (Aβ) that are liberated by γ-secretase, a high molecular weight complex including presenilins, PEN-2, APH-1 and nicastrin. The depletion of each of these proteins...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Company of Biologists
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188804/ https://ncbi.nlm.nih.gov/pubmed/19889971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.051169 |
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