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γ-Secretase Catalyzes Sequential Cleavages of the AβPP Transmembrane Domain

The biogenesis of the amyloid-β peptide (Aβ) is a central issue in Alzheimer's disease (AD) research. Aβ is produced by β- and γ-secretases from the amyloid-β protein precursor (AβPP). These proteases are targets for the development of therapeutic compounds to downregulate Aβ production. γ-secr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijä: Xu, Xuemin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696591/
https://ncbi.nlm.nih.gov/pubmed/19221413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-0957
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