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The GxxxG Motif in the Transmembrane Domain of AβPP Plays an Essential Role in the Interaction of CTFβ with the γ-secretase Complex and the Formation of Amyloid-β
γ -secretase-mediated processing of the amyloid-β protein precursor (AβPP) is a crucial step in the formation of the amyloid-β peptide (Aβ), but little is known about how the substrate AβPP interacts with the γ-secretase complex. To understand the molecular events involved in γ-secretase-mediated Aβ...
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| Опубликовано в: : | J Alzheimers Dis |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633311/ https://ncbi.nlm.nih.gov/pubmed/19625750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1132 |
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