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The GxxxG Motif in the Transmembrane Domain of AβPP Plays an Essential Role in the Interaction of CTFβ with the γ-secretase Complex and the Formation of Amyloid-β
γ -secretase-mediated processing of the amyloid-β protein precursor (AβPP) is a crucial step in the formation of the amyloid-β peptide (Aβ), but little is known about how the substrate AβPP interacts with the γ-secretase complex. To understand the molecular events involved in γ-secretase-mediated Aβ...
Tallennettuna:
| Julkaisussa: | J Alzheimers Dis |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633311/ https://ncbi.nlm.nih.gov/pubmed/19625750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1132 |
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