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Transmembrane substrate determinants for γ-secretase processing of APP CTFβ
The amyloid β-peptide (Aβ) of Alzheimer’s disease (AD) is generated by proteolysis within the transmembrane domain (TMD) of a C-terminal fragment of the amyloid β protein-precursor (APP CTFβ) by the γ-secretase complex. This processing produces Aβ ranging from 38 to 49 residues in length. Evidence s...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5539764/ https://ncbi.nlm.nih.gov/pubmed/27649271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00718 |
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