Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

Cleavage of the amyloid precursor protein (APP) by β- and γ-secretases results in the generation of the amyloid-β protein (Aβ), which is characteristically deposited in the brain of Alzheimer's disease (AD) patients. Inhibitors of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase (the statins) re...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhou, Yan, Suram, Anitha, Venugopal, Chitra, Prakasam, Annamalai, Lin, Suizhen, Su, Yuan, Li, Baolin, Paul, Steven M, Sambamurti, Kumar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859886/
https://ncbi.nlm.nih.gov/pubmed/17666454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-8175com
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