Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through γ-Secretase

Wet age-related macular degeneration (AMD) attacks the integrity of the retinal pigment epithelium (RPE) barrier system. The pathogenic process was hypothesized to be mediated by vascular endothelial growth factor (VEGF) and antagonized by pigment epithelium-derived factor (PEDF). To dissect these f...

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Detalhes bibliográficos
Main Authors: Ablonczy, Zsolt, Prakasam, Annamalai, Fant, James, Fauq, Abdul, Crosson, Craig, Sambamurti, Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781573/
https://ncbi.nlm.nih.gov/pubmed/19723623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032391
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