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Design of substrate transmembrane mimetics as structural probes for γ-secretase
γ-Secretase is a membrane-embedded aspartyl protease complex central in biology and medicine. How this enzyme recognizes transmembrane substrates and catalyzes hydrolysis in the lipid bilayer is unclear. Inhibitors that mimic the entire substrate transmembrane domain and engage the active site shoul...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7359870/ https://ncbi.nlm.nih.gov/pubmed/31999444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13405 |
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