Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage

Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have suggested that the N-terminal part of the C99 transmembrane domain (TMD) is separated from the C-terminal cleavage domain by a di-glycine hi...

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Publicado no:Biophys J
Main Authors: Götz, Alexander, Mylonas, Nadine, Högel, Philipp, Silber, Mara, Heinel, Hannes, Menig, Simon, Vogel, Alexander, Feyrer, Hannes, Huster, Daniel, Luy, Burkhard, Langosch, Dieter, Scharnagl, Christina, Muhle-Goll, Claudia, Kamp, Frits, Steiner, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554489/
https://ncbi.nlm.nih.gov/pubmed/31130234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.04.030
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