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Dissecting conformational changes in APP’s transmembrane domain linked to ε-efficiency in familial Alzheimer’s disease
The mechanism by which familial Alzheimer’s disease (FAD) mutations within the transmembrane domain (TMD) of the Amyloid Precursor Protein (APP) affect ε-endoproteolysis is only poorly understood. Thereby, mutations in the cleavage domain reduce ε-efficiency of γ-secretase cleavage and some even shi...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6028146/ https://ncbi.nlm.nih.gov/pubmed/29966005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200077 |
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