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Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro
Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here we developed a potent “hit” c...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5270246/ https://ncbi.nlm.nih.gov/pubmed/28128331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41487 |
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