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Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of glucose homeostasis and lipid metabolism, and an important target for the development of modern anti-diabetic drugs. However, current PPARγ-targeting anti-diabetic drugs such as classical thiazolidinediones (TZDs) are associa...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7059199/ https://ncbi.nlm.nih.gov/pubmed/32190280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc05487a |
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