Molecular recognition of nitrated fatty acids by PPARγ

Peroxisome proliferator activated receptor-γ (PPARγ) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPARγ ligand binding domain bound to nitrated linoleic acid, a potent endogenous l...

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Detalhes bibliográficos
Main Authors: Li, Yong, Zhang, Jifeng, Schopfer, Francisco J, Martynowski, Dariusz, Garcia-Barrio, Minerva T, Kovach, Amanda, Suino-Powell, Kelly, Baker, Paul R S, Freeman, Bruce A, Chen, Y Eugene, Xu, H Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538624/
https://ncbi.nlm.nih.gov/pubmed/18604218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1447
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