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An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain
The glucagon-like peptide-1 receptor is a class B G protein coupled receptor (GPCR) that plays key roles in glucose metabolism and is a major therapeutic target for diabetes. The classic two-domain model for class B GPCR activation proposes that the apo-state receptor is auto-inhibited by its extrac...
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| Vydáno v: | Cell Discov |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118412/ https://ncbi.nlm.nih.gov/pubmed/27917297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.42 |
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