A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA

Bacterial signaling systems such as protein kinases and quorum sensing have become increasingly attractive targets for the development of novel antimicrobial agents in a time of rising antibiotic resistance. The family of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (P...

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Vydáno v:J Biol Chem
Hlavní autoři: Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Striker, Rob, Sauer, John-Demian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641865/
https://ncbi.nlm.nih.gov/pubmed/28821610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808600
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