Overcoming immunological barriers in regenerative medicine

Por Zakrzewski, Johannes L, van den Brink, Marcel R M, Hubbell, Jeffrey A
Publicado no Nat Biotechnol (2014)

Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends

Por Zakrzewski, Johannes L., Goldberg, Gabrielle L., Smith, Odette M., van den Brink, Marcel R.M.
Publicado em 2007

Clinical Strategies to Enhance T cell Reconstitution

Por Goldberg, Gabrielle L, Zakrzewski, Johannes L, Perales, Miguel A, van den Brink, Marcel R.M.
Publicado em 2007

Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice

Por Tuckett, Andrea Z., Zakrzewski, Johannes L., Li, Duan, van den Brink, Marcel R.M., Thornton, Raymond H.
Publicado no Ultrasound Med Biol (2015)

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Por Holland, Amanda M., Zakrzewski, Johannes L., Goldberg, Gabrielle L., Ghosh, Arnab, van den Brink, Marcel R. M.
Publicado no Semin Immunopathol (2008)

Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency

Por Tuckett, Andrea Z., Thornton, Raymond H., O’Reilly, Richard J., van den Brink, Marcel R. M., Zakrzewski, Johannes L.
Publicado no J Hematol Oncol (2017)

Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy

Por Tuckett, Andrea Z., Thornton, Raymond H., Shono, Yusuke, Smith, Odette M., Levy, Emily R., Kreines, Fabiana M., van den Brink, Marcel R. M., Zakrzewski, Johannes L.
Publicado em 2014

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

Por Vaisitti, Tiziana, Gaudino, Federica, Ouk, Samedy, Moscvin, Maria, Vitale, Nicoletta, Serra, Sara, Arruga, Francesca, Zakrzewski, Johannes L., Liou, Hsiou-Chi, Allan, John N., Furman, Richard R., Deaglio, Silvia
Publicado no Haematologica (2017)

Extrathymic development of murine T cells after bone marrow transplantation

Por Holland, Amanda M., Zakrzewski, Johannes L., Tsai, Jennifer J., Hanash, Alan M., Dudakov, Jarrod A., Smith, Odette M., West, Mallory L., Singer, Natalie V., Brill, Jessie, Sun, Joseph C., van den Brink, Marcel R.M.
Publicado em 2012

Organ-derived dendritic cells have differential effects on alloreactive T cells

Por Kim, Theo D., Terwey, Theis H., Zakrzewski, Johannes L., Suh, David, Kochman, Adam A., Chen, Megan E., King, Chris G., Borsotti, Chiara, Grubin, Jeremy, Smith, Odette M., Heller, Glenn, Liu, Chen, Murphy, George F., Alpdogan, Onder, van den Brink, Marcel R. M.
Publicado em 2008

CCR2 is required for CD8-induced graft-versus-host disease

Por Terwey, Theis H., Kim, Theo D., Kochman, Adam A., Hubbard, Vanessa M., Lu, Sydney, Zakrzewski, Johannes L., Ramirez-Montagut, Teresa, Eng, Jeffrey M., Muriglan, Stephanie J., Heller, Glenn, Murphy, George F., Liu, Chen, Budak-Alpdogan, Tulin, Alpdogan, Onder, van den Brink, Marcel R. M.
Publicado em 2005

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

Por Lu, Sydney X., Alpdogan, Onder, Lin, Janine, Balderas, Robert, Campos-Gonzalez, Roberto, Wang, Xiao, Gao, Guo-Jian, Suh, David, King, Christopher, Chow, Melanie, Smith, Odette M., Hubbard, Vanessa M., Bautista, Johanne L., Cabrera-Perez, Javier, Zakrzewski, Johannes L., Kochman, Adam A., Chow, Andrew, Altan-Bonnet, Gregoire, van den Brink, Marcel R. M.
Publicado em 2008

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

Por Velardi, Enrico, Tsai, Jennifer J., Holland, Amanda M., Wertheimer, Tobias, Yu, Vionnie W.C., Zakrzewski, Johannes L., Tuckett, Andrea Z., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Kreines, Fabiana M., Levy, Emily R., Boyd, Richard L., Scadden, David T., Dudakov, Jarrod A., van den Brink, Marcel R.M.
Publicado no J Exp Med (2014)

Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses

Por Shono, Yusuke, Tuckett, Andrea Z., Liou, Hsiou-Chi, Doubrovina, Ekaterina, Derenzini, Enrico, Ouk, Samedy, Tsai, Jennifer J., Smith, Odette M., Levy, Emily R., Kreines, Fabiana M., Ziegler, Carly G.K., Scallion, Mary I., Doubrovin, Mikhail, Heller, Glenn, Younes, Anas, O’Reilly, Richard J., van den Brink, Marcel R.M., Zakrzewski, Johannes L.
Publicado no Cancer Res (2016)

A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity

Por Shono, Yusuke, Tuckett, Andrea Z, Ouk, Samedy, Liou, Hsiou-Chi, Altan-Bonnet, Grégoire, Tsai, Jennifer J, Oyler, Jennifer E, Smith, Odette M, West, Mallory L, Singer, Natalie V, Doubrovina, Ekaterina, Pankov, Dmitry, Undhad, Chandresh V, Murphy, George F, Lezcano, Cecilia, Liu, Chen, O’Reilly, Richard J, van den Brink, Marcel RM, Zakrzewski, Johannes L
Publicado em 2014

Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation

Por Jenq, Robert R., King, Christopher G., Volk, Christine, Suh, David, Smith, Odette M., Rao, Uttam K., Yim, Nury L., Holland, Amanda M., Lu, Sydney X., Zakrzewski, Johannes L., Goldberg, Gabrielle L., Diab, Adi, Alpdogan, Onder, Penack, Olaf, Na, Il-Kang, Kappel, Lucy W., Wolchok, Jedd D., Houghton, Alan N., Perales, Miguel-Angel, van den Brink, Marcel R. M.
Publicado em 2009

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

Por Zakrzewski, Johannes L, Suh, David, Markley, John C, Smith, Odette M, King, Christopher, Goldberg, Gabrielle L, Jenq, Robert, Holland, Amanda M, Grubin, Jeremy, Cabrera-Perez, Javier, Brentjens, Renier J, Lu, Sydney X, Rizzuto, Gabrielle, Sant’Angelo, Derek B, Riviere, Isabelle, Sadelain, Michel, Heller, Glenn, Zúñiga-Pflücker, Juan Carlos, Lu, Chen, van den Brink, Marcel R M
Publicado em 2008

Absence of P-selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host-Disease

Por Lu, Sydney X., Holland, Amanda M., Na, Il-Kang, Terwey, Theis H., Alpdogan, Onder, Bautista, Jhoanne L., Smith, Odette M., Suh, David, King, Christopher, Kochman, Adam, Hubbard, Vanessa M., Rao, Uttam K., Yim, Nury, Liu, Chen, Laga, Alvaro C., Murphy, George, Jenq, Robert, Zakrzewski, Johannes L., Penack, Olaf, Dykstra, Lindsay, Bampoe, Kevin, Perez, Lia, Furie, Bruce, Furie, Barbara, van den Brink, Marcel R.M.
Publicado em 2010

Donor CD19-CAR T Cells Exert Potent Graft-versus-Lymphoma Activity With Diminished Graft-versus-Host Activity

Por Ghosh, Arnab, Smith, Melody, James, Scott E., Davila, Marco L., Velardi, Enrico, Argyropoulos, Kimon V., Gunset, Gertrude, Perna, Fabiana, Kreines, Fabiana M., Levy, Emily R., Lieberman, Sophie, Jay, Hilary, Tuckett, Andrea Z., Zakrzewski, Johannes L., Tan, Lisa, Young, Lauren F., Takvorian, Kate, Dudakov, Jarrod A., Jenq, Robert R., Hanash, Alan M., Motta, Ana Carolina F., Murphy, George F., Liu, Chen, Schietinger, Andrea, Sadelain, Michel, van den Brink, Marcel R.M.
Publicado no Nat Med (2017)

c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis

Por Leslie, Jack, Macia, Marina García, Luli, Saimir, Worrell, Julie C., Reilly, William J, Paish, Hannah L, Knox, Amber, Barksby, Ben S, Gee, Lucy M, Zaki, Marco Y.W., Collins, Amy, Burgoyne, Rachel A, Cameron, Rainie, Bragg, Charlotte, Xu, Xin, Chung, Git W, Brown, Colin DA, Blanchard, Andrew D, Nanthakumar, Carmel B, Karsdal, Morten, Robinson, Stuart M, Manas, Derek M, Sen, Gourab, French, Jeremy, White, Steven A, Murphy, Sandra, Trost, Matthias, Zakrzewski, Johannes L, Klein, Ulf, Schwabe, Robert F, Mederacke, Ingmar, Nixon, Colin, Bird, Tom, Teuwen, Laure-Anne, Schoonjans, Luc, Carmeliet, Peter, Mann, Jelena, Fisher, Andrew J, Sheerin, Neil S, Borthwick, Lee A, Mann, Derek A, Oakley, Fiona
Publicado no Nat Metab (2020)